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John Messina Selected Research

Tablets

5/2015AVP-825 breath-powered intranasal delivery system containing 22 mg sumatriptan powder vs 100 mg oral sumatriptan in the acute treatment of migraines (The COMPASS study): a comparative randomized clinical trial across multiple attacks.
6/2012Assessment of the relative potency of fentanyl buccal tablet to intravenous morphine in healthy volunteers using a thermally induced hyperalgesia pain model.
7/2011Effect of fentanyl buccal tablet on pain-related anxiety: a 4-week open-label study among opioid-tolerant patients with chronic and breakthrough pain.
3/2011The efficacy and safety of fentanyl buccal tablet compared with immediate-release oxycodone for the management of breakthrough pain in opioid-tolerant patients with chronic pain.
1/2011Aberrant drug-related behavior observed during clinical studies involving patients taking chronic opioid therapy for persistent pain and fentanyl buccal tablet for breakthrough pain.
11/2010Long-term safety and tolerability of fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic pain: an 18-month study.
9/2010A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic pain.
7/2010Consistent and clinically relevant effects with fentanyl buccal tablet in the treatment of patients receiving maintenance opioid therapy and experiencing cancer-related breakthrough pain.
6/2010Fentanyl buccal tablet for the treatment of breakthrough pain: pharmacokinetics of buccal mucosa delivery and clinical efficacy.
6/2009Fentanyl buccal tablet for the treatment of breakthrough pain in opioid-tolerant patients with chronic cancer pain: A long-term, open-label safety study.
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John Messina Research Topics

Disease

14Breakthrough Pain
07/2011 - 11/2006
13Pain (Aches)
05/2015 - 01/2007
8Neoplasms (Cancer)
11/2010 - 11/2006
7Chronic Pain
07/2011 - 07/2007
4Cancer Pain
06/2009 - 01/2007
4Nausea
01/2008 - 03/2002
3Dizziness (Lightheadedness)
01/2008 - 04/2007
2Migraine Disorders (Migraine)
05/2015 - 01/2015
2Vomiting
04/2007 - 03/2002
2Alzheimer Disease (Alzheimer's Disease)
03/2002 - 08/2000
1Glycogen Storage Disease Type II (Pompe's Disease)
01/2020
1Disease Progression
01/2020
1Hyperalgesia
06/2012
1Miosis
06/2012
1Pneumonia (Pneumonitis)
03/2011
1Opiate Overdose
01/2011
1Substance-Related Disorders (Drug Abuse)
01/2011
1Fatigue
07/2007
1Sleepiness
04/2007
1Postherpetic Neuralgia
04/2007
1Neuralgia (Stump Neuralgia)
04/2007
1Peripheral Nervous System Diseases (PNS Diseases)
04/2007
1Complex Regional Pain Syndromes
04/2007
1Low Back Pain (Lumbago)
01/2007

Drug/Important Bio-Agent (IBA)

16TabletsIBA
05/2015 - 11/2006
15Fentanyl (Sublimaze)FDA LinkGeneric
06/2012 - 11/2006
14Opioid Analgesics (Opioids)IBA
07/2011 - 11/2006
6Pharmaceutical PreparationsIBA
05/2015 - 04/2007
2Sumatriptan (Imigran)FDA LinkGeneric
05/2015 - 01/2015
2PowdersIBA
05/2015 - 01/2015
2Rivastigmine (Exelon)FDA LinkGeneric
03/2002 - 08/2000
1Tryptamines (Triptans)IBA
05/2015
1LactoseFDA LinkGeneric
01/2015
1Morphine (MS Contin)FDA LinkGeneric
06/2012
1Opiate AlkaloidsIBA
06/2012
1Oxycodone (Oxycontin)FDA LinkGeneric
03/2011
1AntiemeticsIBA
03/2002

Therapy/Procedure

5Therapeutics
01/2011 - 01/2007
3Analgesia
01/2008 - 07/2007
1Enzyme Replacement Therapy
01/2020
1Activities of Daily Living (ADL)
08/2000